Precision radiation, delivered cell by cell.
Targeted alpha therapy pairs a tumor-seeking ligand with a high-energy alpha emitter — concentrating cytotoxic dose within a few cell diameters of the target, and building on the radioligand foundation clinical teams already know. [POTENTIAL TO ELEVATE ACTINIUM FURTHER HERE]
A distinct radiation profile
Alpha particles carry more mass and energy than beta particles, and they travel a much shorter distance — which changes the pattern of DNA damage they leave behind. Linear energy transfer (LET) is a shorthand for how densely a particle deposits energy along its path; alpha's high LET packs more damage into a shorter track. Beta is shown alongside for reference.
Alpha particles
- Particle
- Helium nucleus (2 protons + 2 neutrons)
- Energy
- ~5–9 MeV
- Range in tissue
- ~40–100 μm (2–10 cell diameters)
- LET (energy density)
- High (~80 keV/μm)
- Dominant DNA damage
- Clustered, irreparable double-strand breaks
Beta particles
- Particle
- Electron
- Energy
- ~0.5–2.3 MeV
- Range in tissue
- ~1–10 mm (~100–1000 cell diameters)
- LET (energy density)
- Low (~0.2 keV/μm)
- Dominant DNA damage
- Predominantly single-strand breaks
Investigational status
RYZ-101 is an investigational agent and has not been approved by the FDA or any other regulatory authority. The safety and efficacy of RYZ-101 have not been established. This page is for healthcare professional education and does not constitute promotion of an unapproved product or use.